The delegation of the Siberian Branch of the Russian Academy of Sciences (RAS), led by Valentin N. PARMON, Chairperson of the Siberian Branch of RAS and Academician of RAS, visited our university.
The visit included a meeting with Prof. Maria A. LIVZAN, MD, Dr Sci (in Medicine), Rector of OSMU, Corresponding Member of RAS; Prof. Olga V. KORPACHEVA, MD, Dr Sci (in Medicine), Vice-Rector for Research; Assoc. Prof. Andrey S. KOLCHIN, MD, PhD (in Medicine), Vice-Rector for Postgraduate Education and Digital Transformation; Anna P. SOLONENKO, PhD (in Chemistry), Head of the Scientific Laboratory of the Faculty of Dentistry; Assoc. Prof. Dmitry G. NOVIKOV, MD, PhD (in Medicine), Head of the Central Research Laboratory; and the authors of the university's most relevant and promising projects, implemented in part with the support of the Russian Science Foundation. As interim results of the university's ongoing scientific and innovative activities, five projects were presented.
Assoc. Prof. Sergey I. MOZGOVOY, MD, Dr Sci (in Medicine), Prof. of the Morbid Anatomy Department, discussed the project of a research team from two scientific schools: gastroenterology and morbid anatomy, headed respectively by Prof. Maria A. LIVZAN and Prof. Alexey V. KONONOV, MD, Dr Sci (in Medicine), Honored Scientist of the Russian Federation. The interdisciplinary project team creates a smart clinical decision support system (standard protocols, marker panels, risk stratification models, etc.) and a digital twin of a patient with precancerous gastrointestinal diseases. The project's methodological basis is based on the principles of 5P medicine. The development of fundamental diagnostic tools for inflammatory and precancerous diseases of the digestive tract will enable the transition to intelligent clinical support systems in the relevant field of medicine.
Assoc. Prof. Dmitry G. NOVIKOV, Head of the Central Research Laboratory, presented a study on NETosis—neutrophil extracellular traps (NETs). The results of this research identified various immune response patterns with correlations between the ability of neutrophil leukocytes to form NETs, the morphological characteristics of NETs, the level of the immunohistochemical marker NETosis, and other factors in septic and aseptic inflammatory processes, which form the pathophysiological basis of various diseases. The researchers use a modified proprietary method that improves the quality of diagnostics, laboratory monitoring of treatment, monitoring of cure, and risk stratification for relapse of certain diseases and pathological processes. At the final stage of the project, the team plans to present a unified diagnostic test system, the "Netosis Test," for widespread implementation in clinical practice.
Anna P. SOLONENKO, Head of the Scientific Laboratory of the Faculty of Dentistry, presented the results of her research in the field of "Biocompatible Ceramic Materials for Bone Defect Replacement," covering everything from the development of synthesis methods to the study of the mechanical, physical, and biological properties of composite materials: calcium phosphate and silicate composites, hardystonite, calcium hydroxyzincate, and others. Specifically, she presented original composite granules with a core-shell structure and porous blocks for densely filling bone defects and protecting underlying tissue.
Pavel A. ERMOLAEV, MD, PhD (in Medicine), Assoc. Prof. of the Department of Topographic Anatomy and Operative Surgery, introduced the project to develop perfusion systems for prolonged anti-ischemic protection and reconditioning of donor organs. The project is being implemented in collaboration with scientists and engineers from Omsk State Transport University. The goal of the project is to create and commercialize a domestically produced portable perfusion machine that will reduce the shortage of donor organs in the country by increasing their "storage" time (the journey from donor to recipient) and by expanding the resuscitation capabilities of initially compromised organs currently considered unsuitable for transplantation.
Alexander V. KHIZHUK, DMD, Associate Professor of the Department of Prosthodontics, presented the results of his research in the field of "Application of Digital Technologies in Prosthodontics Rehabilitation." The presented products clearly demonstrated how the use of digital technologies at the diagnostic, planning, and fabrication stages contributes to improving the quality of prosthodontics rehabilitation. The proposed protocols and prostheses are already being used not only in Omsk, but also at the N.P. Napalkov Oncological Center in St. Petersburg.
Following a brief discussion summarizing all the presentations, members of the RAS delegation learned from Prof. Alexey V. KONONOV about the history, development, and current status of the Omsk School of Morbid Anatomy and the activities of the University's Academic Center for Morbid Anatomy.
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